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Point of no return 

When ear stretching this is the point where the ear will not heal or go back to normal. It varies in people but it is on average 6mm
Person 1: Wow look at that dude woth the 50mm ear stretcher!
Person 2: He has gone way past the point of no return!
Point of no return by LambertLover September 17, 2012

Point of No Return 

A point at which the player may not turn back. You may not revisit any prior locations or start any missed sidequests; you MUST continue your journey until you beat the game, and any content you avoided up to this point may not be reached.

The Point of No Return is always preceded immediately by the Point of Safe Return, which is the last chance to do sidequests or stock up for the journey. Similar Plot Tunnels lock the player onto a set course for a while, but they don’t lead straight to the end of the game. Game Levels are where you’re frequently prevented from returning to previous areas.

The term “Point of No Return” originates in aviation, where a plane that crosses this point must continue toward its destination.

Point of No Return, Plot Tunnel, and Game Level all have pages on TV Tropes, where you can read more about them and what games they’re in.
SAVE GAME?
This is your last chance to save the game. You are about to cross the Point of No Return. If you do decide to save your game, keep the save file handy should you need to come back.
Yes No

point of no return 

the point on a poorly made urinal, where the least amount of piss bounces back on to your trousers
hey man, did you piss on your leg?
oh yeah, i couldn't find the point of no return on that shitty urinal
point of no return by kosherbacon January 3, 2011

Point of no return theory 

The point of no return theory is when you take a member of the opposite sex (usually female) home to have sexual relations/fellatio. As you take off your clothing, she realizes that you have a tiny penis and/or a beer belly, but since you have already gotten to this point she might as well hook up with you--hence the point of no return. Essentially, a common bond amongst the ugly people of America where hope is found.
Once my pants came off she had to keep going--proof of the Point of no return theory.

the point of no return 

the 3-5 seconds before you blow your wad
Phil: cassie..i'm...i'm...gonna...
Cassie: *suck, slurp* oh *orgasms* your cock is so hard! *another orgasm*
Phil: i've entered the point of no return!
*4 seconds later*
Cassie: I love swollowing your cum!
the point of no return by Phil March 17, 2004

the point of no return 

-When drinking beverages of an alcoholic nature, when a certain number drink (ie. beer #12) puts you "over the edge"
-Passing the point of no return will usually result in loss of memory, speech, and motor skills.
Friend: Dude, drink that beer you'll be passed the point of no return, dont expect me too carry your drunk ass around all night
Friend 2: (incoherent babble) (chugs beer)