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Show biz slang for hyper positive attitude. From the legendary rallying cry of the lead chorine for Broadway shows, just before they go on stage -- "Tits up, girls!" Usually an adjective -- a tits up attitude, taking the tits up approach, they want someone who's totally tits up for the job.
Everything is going to shit but my boss is so tits up I may have to kill him.

They want to see a lot of tits up attitude this quarter, when the new product rolls out.
tits up by old lang guy October 17, 2006
Best used as a negative adjective when describing what you hope will result in a relationship, situation, or vacation.
I hope it goes tits up in Corfu.
tits up by mggiedixon August 21, 2009
"You're going down, man, tits up.
tits up by Reddog500 August 8, 2006
Chillin. BIG chillin. Relaxing. Coolin. UNBOTHERED.
I’m so tits up that I can’t find my neck right now.
Tits Up by Titsupnoneck August 25, 2019
Denotes a symbolic congratulatory salute from a group of females. Used by female teams.
Cathy got red carded last night after a scuffle with that pushy witch on the other team. Hats off, three cheers, and tits up to Cathy!
tits up by jrkfrsf July 24, 2009
Tits up can refer either to:

1. In the case of posture, this refers to the woman lying on her back: i.e.: supine.

2. In other contexts, it refers to something broken down or in a state of disrepair.
Context #1:

She was tits up; ready and willing,

Context #2:

My old Studebaker finally went tits up: good for parts only.
tits up by Angel of the Morning April 24, 2021