to come up on somethin, to find something of value such as a $20 bill on the ground. Also to rise to the top financially
by nor-cal March 07, 2004

To make it big, bubble.
by yanar October 26, 2004

The point at which the drugs kick in, usually after taking amphetamines, halluciogens or substances such as MDMA (ecstascy).
by uphoriak April 13, 2005

by faggotskillgays December 06, 2016

Stacy was just a bartender at Applebee's when she met that basketball player. She snagged the ultimate come up.
by Sidewinder01 September 19, 2012

"Ay fool, you wanna come up on that watch we saw at the jewelery store"
"Dawg, we gotta come up on some shit at this house party tonight"
"Dawg, we gotta come up on some shit at this house party tonight"
by dubbedoutgeo July 03, 2006

by Ellekaybe January 01, 2015
