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I don't know what I'm going to do with you! 

Significant other is fed up or exhausted with the idea of you being around them.
Justin, you are getting to be too much and I'm confused about how I should handle you! You have made me mad/annoyed for the last time!!
("I don't know what I'm going to do with you!" is to be aggravated or annoyed by one's actions)

I don't know what that means 

A common response that happens when an asker made a point
but the receiving end felt offended and looked down on the question.
Then quipped by the receiving end!
A: Hey any tips on how to make money?

B: I don't know what that means.

I don't know what X means, but it sounds disappointing 

A phrase used by anyone who knows it. which displays a "I don't care, but i do at the same time" feel when its said.
The X can be replaced with anything, but depending on what X is changes "what" and "means", if its a person, it would instead be "who" and "is".
Usually saying this phrase, they put on a depressed tone and slur their words, specifically "sounds", and "disappointing". Usually said like : "Soounds Disappoooointingg..."
I don't know what X means, but it sounds disappointing.
1. Hey, meet my friend Bob!
2. I don't know who Bob is, but it sounds disappointing...
~or~
1. Try this food!
2. I don't know what food means, but it sounds disappointing ...

I don’t know what to do

UD Jews, I’m talking to you guys

I’m very confused and am unsure as to what I should do.

My friend said I know the truth and that I shouldn’t be worrying. But things are getting really tough.

Will the stock market crash soon or will WW3 break out soon? That would kinda give me an advantage.

I don't know what to look up 

What did you think was gonna pop up? THINK ABOUT HOW TO MAKE PROGRESS IN LIFE! THINK ABOUT WHAT YOU WILL DO! Learn some Spanish or meditate. Go for a jog come on, you got this!
Bob, (Searches "I don't know what to look up, then sees this) "I WILL FIX MY LIFE STEP BY STEP!

I don’t know what you’re talking about 

When George makes things up and accuses Aya of things she hasn’t done
Babe you can’t keep uploading definitions in the internet!!

I don’t know what you’re talking about…