2-2

.22 caliber.
A small rimfire cartridge, used for target shooting.
Three variations of .22 caliber exist: .22k (short), .22lr (long rifle), and .22WinMag (Winchester Magnum).
Sometimes used incorrectly to refer to a derringer, which is often chambered in a larger caliber.

"He didnt think I was packing, so I busted out my 2-2 and copped me a 187"

by .357ROB September 30, 2003

2-by-2

Also known as a 4-by-4 (or any multiple of 2). Describes someone with an abnormally large ass.

"She's got a 2-by-2 on her, don't she?"
"I gotsh me a 4-by-4"

by Cowboy Chick February 7, 2014

2 of 2

When a time stamped cup confirms your spouse is cheating on you.

My husband went out to get groceries and I found a Starbucks cup in my car that read 2 of 2. Hmmmm interesting....

by #notmyproblemanymore July 27, 2017

2+2

IF YOU DON'T FUCKING KNOW THIS YOU PIECE OF DOG SHIT, YOU WILL NOT GET ANYWHERE IN FUCKING LIFE!!!!

Hey! did you know that 2+2=4?

by QueerFace June 17, 2013

2+2

A type of fish

Teacher: what's 2+2?

Kid: 4

Teacher: If magic was real it would equal fish.

by Anonymous9056 March 16, 2018

2+2

Having received two Pfizer or Moderna COVID shots (or one J&J) and passed the two-week waiting period.

"Hey hottie, I'm 2+2!"

by Gwilpak Ziipster May 10, 2021

2 & 2

To figure out and come to a conclusion. Usually in reference to something incredibly simple.

Guy 1: What's taking you so long?
Guy 2: I can't remember which key locks the deadbolt.
Guy 1: Well 2 & 2 that shit, I wanna hit the bars while we're young.

by Scott Friday December 18, 2008