by Peter Buttram, Proctologist/Asstronut August 11, 2006

What is irritating that person that they are so annoying you don't want to be around them.
The other way to define it is "What's crawling up your ass!"
The other way to define it is "What's crawling up your ass!"
by JillsCrazyPlace February 3, 2010

A dismissive way to answer someone annoying you for help, or just to be an asshole. Especially useful at work.
"Where can I find the foot-long dildos?" "Up your ass & to the left."
"Did you get that memo from the staff meeting?" "Yeah, it's up your ass & to the left."
"Did you get that memo from the staff meeting?" "Yeah, it's up your ass & to the left."
by Dharma Midget December 16, 2019

Milsey approaches liss and says hey liss what are you doing.
Liss ignores milsey and milsey then says "What is up your goat "?
whats up your goat?
Liss ignores milsey and milsey then says "What is up your goat "?
whats up your goat?
by liss_misley_mad January 17, 2012

by Yep, I did it, so what? May 18, 2016

by bobbyt June 18, 2006

by Zoe89 December 1, 2009
