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Acronym:

You
Only

Live

Once

Basically, the only way to live life. Since, because, pickles. Playing it safe is the most popular way to fail.
Bcheese: Dood?! Should I go yell "How Much?" to those babes down the street?

Gfuel: Hell yea man, YOLO.
YOLO by G-Fuel 69 July 30, 2010
Related Words
The lame excuse to do stupid stuff
drinking, drugs, getting high, sex with multiple people yolo
YOLO by adree_marie September 29, 2012
a stupid acronym wannabes and "cool" people use.It means "you only live once" which is obvious and stupid because everybody already knows "you only live once"(Its not like you're Jesus or something).
Timmy:YOLO!
random guy:shut the fuck up Timmy
other guy:No,actually Timmy's right *holds up gun and pulls trigger* YOLO Timmy!*BOOM!*
YOLO by 1-800retards united December 4, 2013
v. the abbreviation of "you only live once." used as a verb for doing something badass, something that takes balls, or something a person wouldn't do on the normal everyday basis.
Kelsey is going to yolo tonight, shes about to sneak out the window to have sex with her best friends boyfriend.
yolo by gettsomee May 9, 2009
You Only Live Once...I believe this was the philosophy of Average Joe Returns star Adam Mesh.
Should I take my Jeep on the Cliff Hanger Trail in Moab.

YOLO...man. Let's do this.
YOLO by Randy Harris April 30, 2004
Yolo doesn't mean having sex, it doesn't mean doing drugs, it doesn't mean anything else that is considered uncivilized.

Yolo is doing something that really matters in your life, something that will actually make you a somebody, something that will change your life.

Life is shorter than we think, don't waste it.
You only live once. ;)
Yolo, don't be stupid. Do something in you life.
Yolo by Lang Li December 9, 2012