The weariness and the hopelessness one feels when battling chronic issues (mental and/or physical) on a daily basis.
by Kennek July 23, 2021

Sometimes known as the ladies' hangover (although men can get them too), its a classier way of saying you're feeling a bit under the weather after a night of drinking, particularly wine. Appropriate for use in mixed company such as at the office or family gatherings.
Julia, you had a lot to drink last night, are you feeling hungover?
No, I'm fine, just a little wine fatigue.
No, I'm fine, just a little wine fatigue.
by Duchess V November 17, 2017

the abandoning of any true use or productivity in a journal or other written medium because too much time, energy, and anxiety have been poured into making pretty layouts.
Trish's future log, monthly log, and daily logs all have adorable colorful kittens drawn in all the margins, but she now has too much journaling fatigue to actually use her new Bullet Journal.
by Demo318 January 5, 2019

by periaqua May 15, 2020

It's the malady that sets in when the user realizes "services" like Foursquare are a complete and utter waste of time.
Hey, I just became Mayor of my workplace! When do I get my pay rise?
Heh - that's only because Mary stopped checking-in on Foursquare. She has total check-in fatigue.
Heh - that's only because Mary stopped checking-in on Foursquare. She has total check-in fatigue.
by Doomnation September 2, 2010

A syndrome sweeping the nation after being inundated with too much Sarah Palin. Signs of it's effect are nausea, irritability, annoyance and frustration. Sufferers frequently feel they must resort to leaving the online and television worlds for immediate relief as she can show up in any venue from national news, comedy, politics to entertainment.
Man - I got Palin Fatigue. If I see her face on one more book cover or reality show, I'm gonna hurl. She's everywhere!!! Aaah!!!!
by bklyngrl January 22, 2011

A condition occuring over time to chronically ill patients who have to take a lot of medication, in which the patient stops taking pills because of the stress and monotony of constant pill swallowing.
"I am so tired of taking all my HIV meds. I'm full before I ever get anything to eat."
"Hey man, don't be giving in to pill fatigue now."
"Hey man, don't be giving in to pill fatigue now."
by kitandcaboodle September 9, 2008
