One of the main and most important characters on the medical drama House, M.D. He is called 'Wilson' by most and is House's best friend. There is a large fandom surrounding the House/Wilson relationship and the writers have admitted to putting some subtext involving them into the dialogue.
Dude, did you see James Wilson's hair yesterday?! CRAZY SHIT!!
Stacy: What are you hiding?
House: I’m gay
House: Oh that’s not what you mean. Does explain a lot though, no girlfriend, always with Wilson
Stacy walks off
House: ……. obsession with sneakers….
Stacy: What are you hiding?
House: I’m gay
House: Oh that’s not what you mean. Does explain a lot though, no girlfriend, always with Wilson
Stacy walks off
House: ……. obsession with sneakers….
by dudeup! July 20, 2007
Get the James Wilsonmug. A great boyfriend who is unconfident at first but doesn't know girls love and adore him. He's usually pretty popular and has tons of friends. He knows exactly what girls want. He's really good at cooking and making girls laugh. Even though he likes to hang with girls he's not a cheater or a simp. He respects women and his girlfriend.
Girlfriend- I love you, but all the girls also do
James - Dont worry your the only one for me. Ill never ever cheat on you.
Girlfriend - I know, I know
James - Dont worry your the only one for me. Ill never ever cheat on you.
Girlfriend - I know, I know
by ilovejames1231 November 3, 2020
Get the Jamesmug. by yeetyeetimasheep September 18, 2020
Get the Jamesmug. A narcissist , run away
by Mk45 October 11, 2020
Get the Jamesmug. 
by I_Love_James November 16, 2020
Get the Jamesmug. James is the type of guy to get girls but doesn’t care and is the homie that’s usually is high and with has a big dick
by Tocoolfieurmom818 October 29, 2019
Get the Jamesmug.