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One of the main and most important characters on the medical drama House, M.D. He is called 'Wilson' by most and is House's best friend. There is a large fandom surrounding the House/Wilson relationship and the writers have admitted to putting some subtext involving them into the dialogue.
Dude, did you see James Wilson's hair yesterday?! CRAZY SHIT!!

Stacy: What are you hiding?

House: I’m gay

House: Oh that’s not what you mean. Does explain a lot though, no girlfriend, always with Wilson

Stacy walks off

House: ……. obsession with sneakers….
by dudeup! June 20, 2007
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