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Life Mistress 

The friend you pick up after you drop off your girlfriend; the interaction between you is not a sexual one, but she could destroy you with the information she's gathered about your life.
Hey life mistress, remember when you ran to get me more beer even though you couldn't walk? I'm sure glad my girlfriend was asleep
Life Mistress by Stonee November 2, 2010

Medical Mistress 

1. A married doctor's love interest

2. A married doctor's love interest who coaxes said doctor to separate/divorce his wife to be with her (mistress)
A medical mistress is whomever a male doctor cheats on his wife with or leaves his wife for
Medical Mistress by Orenn May 12, 2013

Good Mistress 

A whore that know the rules of being a worthless tramp. SHe knows that the married man she is screwing has zero respect for her, knows he only want/needs her for sex and "dirty" sex, this mistress also knows that the man will never leave his wife for a slut like herself. She knows her place that wife is always first. The mistress also knows that 1 day a week, no phone calls, no texting, no messages IS the only way to go.
The MOST important rule is to KEEP YOUR DAMN MOUTH SHUT! If a whore forgets even 1 rule, they are not a good mistress. If the whore forgets and talks about the affair she deserves to have the wife whoop her ass AND public humiliation so everyone who will listen will know what a worthless deviod human being you really are!
Man "ya, girl.......your such a good mistress, my wife won't suck my cock after I put it in her ass!"

"Thanks, sweetie for keeping your mouth closed when my wife called you, now open it and do what a good mistress does!"

"Shut up whore, I told you NOT to call my house you are NOT a good mistress!!"
Good Mistress by MikeytheTRUTH December 10, 2009

cisgender house mistress 

Proud house wife.
My husband loves coming home to his cisgender house mistress.

freak mistress 

ANOTHER fit lass i met on faceparty.com (more advertisin) but hshe has cooler hair dammit
mm freakmistress
freak mistress by JIMBO May 14, 2003

We Killed Mistress  

Also known as WeKM The most bitchinest band ever to hit the east coast bitches! we be straight up killing it up in here ya heard. add us on myspace
We killed mistress is the shit and your all jealous of there skillz and you should add those niggas on myspace.