When one gets punched in the face so hard that you could compare the force of it to a Mack truck coming full speed. Basically another word for getting knocked out cold.
Jon: Yo, did you see that street fight earlier today?
Marco: Yeah bro, Tony got macked in the face! He couldn't even get up.
Marco: Yeah bro, Tony got macked in the face! He couldn't even get up.
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