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What the American military has referred to the enemy as since the Vietnam War. Comes from the abbreviation for Vietcong, VC. Using the NATO Phoenetic Alphabet, this translates to Victor Charlie. It's not a racial slur for Vietnamese. It's the enemy.
"HOLY SHIT! Charlie's flankin us!"
charlie by B-ROD July 18, 2008
In the UK Charlie is slang for cocaine. Dunno about the rest of the world but in the UK it’s a total waste of money as it’s cut up with all kinds of crap so you barely get any kind of high out of it.
Guess what? I’m gonna stop doing Charlie. It’s so overrated.
charlie by Stratostreak December 7, 2006

Charlie Mack 

To be pimp. To keep your pimp hand strong. To be loved by and to love many ladies regardless of whos girlfriend they are. To be a self proclaimed "makeout whore" and "best kisser this side of the mississippi river".

see: chuck bravo
Joe: Hey, isn't that Mike's girlfriend hes making out with?
Tim: God, he's so pulling a Charlie Mack right now.

Charlie Mack by TheAviator528 December 9, 2008

charlie wilkinson 

a man with a big cock who is really good at fortnite

Charlie Weis 

Head football coach at Notre Dame and greatest person alive today.

common variants: Carroll Killer, The Jersey Jesus, Mr. Tremendous, Belichick jr.
"Man, Charlie Weis should be the President in the offseason."
Charlie Weis by Mr. TT October 16, 2005

cheesy charlie

The act of placing seran wrap on a person's face and then excreting fecal matter onto it. Another term for a hot plate.
You don't have to go to Chucky Cheese's to get cheesy anymore kids!
cheesy charlie by Niggslayer June 19, 2004