A retort/response to someone you are arguing with.
Ex: When you are arguing with your significant others mom (Regardless of her name) "Fuck you Denise" is said to shut her ass down.
by heelside336 August 1, 2017
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a drug dealer who works a fast food joint and uses secret code with their customers.
Crackhead Joe: "Is Denise working...I feel a little bit more comfortable ordering from Denise"

Denise: "89 CENTS"

Crackhead Joe: That's still cool?

taco bell Denise hands Joe a "5 layer burrito" filled with crack, while Joe hands over a Taco Bell bag full of money saying he didn't get any sauce
by tacobelles April 14, 2010
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a smart girl who everyone loves. oftentimes a denise will be a libra with longish curly hair. denises' are often very short and thick and known to have a big ass. most denises' believe that they are greater than everyone else which is actually true!
boy 1 : i love her
boy 2 : of course you do, she's a denise!
by iheartmilk May 14, 2021
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Denise is the definition of perfection, she is a loyal, loving and caring girlfriend and she is guarded by her great family. If there's a Denise in your area be quick and ask them out, there's always a good chance.
Guy 1: That girl is sooo fine
Guy 2: Hey, that's my Denise you're talking about
by churro_muncher<3 May 24, 2022
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Denise is a whore that switches from guy to guy
by Abraham Dingleberry February 15, 2023
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