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A slang word for an indevidual with mental disabilities or a complete idiot it is an insult and another way of calling someone a retard or idiot
Jimmy did something so stupid he is such a chromosome
by Ilikejackitsme June 20, 2017
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slang for a short pool cue that is used when a pool table is in an area wear there is not enough room to use a full sized cue. called a chromosome because using it makes you feel slightly retarded and that the cue itself is retarded.
pass me the chromosome, i dont have enough room to make this shot.
by ulrichwulf February 19, 2010
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Slang for the word man, or homie, or nigga. Mainly produced as a white man's version of the Bay Area term: Rogue. Used in the 650, mainly West Menlo Park. Created by two white boys from West Menlo park.
Alternative Term: Chromo.
Wasssupp Chromosome.
Just Chilling Rooogue.
by Mi0s April 25, 2007
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Black guy: who is comin over, man?
White guy: A few of my chromosomes.
by Andy Y. August 6, 2007
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The world 'chromosome' is usually used to bully someone
GameGod22: Hey Burt, I didn't like how you said Hello yesterday
Burt: Idc I have more chromosomes then you

*GameGod22 goes crying**
*GameGod22 kills himself**

Burt: Well that's 1 less chromosome to handle!
by BlockBoy72 July 6, 2018
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Chromosome powerplay

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Meaning you have an extra set of chromosomes. Nice way of calling someone a retard. Powerplay is a man-up scenario in sports, mostly from opposing team serving a penalty.
Person 1: "Wow, that guy is a moron."

Person 2: "Yeah, they must have a chromosome powerplay going on."
by M_Dubz152 June 6, 2023
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