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A 'lady of the night' or 'working girl' that is not a viable 'purchase'. Reasons can include possible fore knowledge of certain diseases...past relations with family or close friends...or actual relation to you as a family member.

The term can also be loosely applied to females or even males who are of the low sexual moral standpoint and who are also well avoided in the sexual arena.
Me and Jake wandered around the corner from the proper red light district into the seedy back alleys...but we ran back after seeing nothing but 'no-go-hos'.

My cousin is a slut...but my uncle would cut my sack off...so she is a no-go-ho!
no-go-ho by Dave Luke Ford October 11, 2006

No Go Hole 

Another word referring to an Asshole.
"Dude, Just put it in her No Go Hole."
No Go Hole by Mark Book April 22, 2006

No-go hoe 

Someone notoriously known for being a hoe yet cannot have possibly have had sex.
Billy: damn that girl is fine!
Jim: yeah but sister Mary is a no-go hoe

No Go Homo 

No Go Homo is a bill stating that homosexual marriage should be banned..this bill is awaiting to be passed by a group of students in 1st period government.
Danny (the gay boy): what should this bill be called?

Jenna: NO GO HOMO!
No Go Homo by Jenna.B! April 24, 2008

No go home 

A phrase you use when you want someone to leave you house you idiot.
Guy 1: Hey do you wanna hang out?
Guy 2: No go home I’m busy.
Guy 1: Oh, ok

Go die in hole with no cable

a smart-ass remark just to be funny
" i freking hate you , go die in hole with NO cable. "
"you know what ?! you can go die in hole wiht NO cable! "