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The general rule that you should always bring a towel just in case you do something stupid so at least people will say "Hey that guy/gal really knows where their towel is". Coincidentally this is also the meaning of life and all questions because all answers can be deprived from 42 an example of this would be: How many minutes dose it take to make a marshmallow peep answer 42 because 4+2=6 and it takes 6 minuets to make. Part of the 100+ general rules of the universe.
Bob: What should I bring to my camping trip to Death Vally?

Jim: Always remember Rule 42: Always bring a towel.

Bob: Why? a towel there is no reason I would need it.

Jim: But what if you get lost then with a knife and a little time you can make a turban like hat to shield your eyes so you don't over heat and go temporally blind, or what happens when you need some sort of bag but you only have a knife a towel and some rope you could make your own knapsack.

Bob: Thanks Jim for reminding me about Rule 42.

Jim: No problem.
Rule 42 by Raegon December 9, 2008
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If it exist, ther is a pony version of it.
Rule 42 by janniluk October 30, 2011
If it exist, there is a pony version of it. No exceptions.

Started by the brony fanbase of My Little Pony: Friendship is Magic.
There is nothing wrong with non-ponified things, ponifying just makes them around 20% cooler.
rule 42 of zoidberg meme: "Need a new zoidberg? why not pinkie pie?"
rule 42 by DutchBrony October 30, 2011
In Wonderland, a rule of the Queen of Hearts' court stating all persons more than a mile high must leave the court immediately.
King: "Rule 42, all persons more than a mile high must leave the court immediately!!"

Alice: "I am not a mile high, and I'm not leaving."
Rule 42 by Disnevytte August 30, 2010
If it’s a flavor, someone has vaped it.

Props to you if you know where this is from.
F1: Do you have expressed anal gland vape juice?
F2: Yeah, I got some.
F1: Can you mix that anal gland juice with this onion?
F2: Damn bro, you a juiceologist?
F3: What the fuck is wrong with these people... Rule 42 knows no bounds.
Rule 42 by Bruhsepphu May 10, 2020
Compassion
Forgiving others who have hurt you
Healing
I am showing rule 42 towards your situation.
Rule 42 by Project Legion October 20, 2021
a: "i cannot believe they are de-sanctifying Mother Mary in this atrocious satanic collage!"
b: "well, nothing is sacred. rule 42 lady..."
rule 42 by superfail March 7, 2009