Psycho Killer Bitch Syndrome. This is for someone who reacts very cynically. Someone who is very hostile, crazy, or who has lost their grip on reality. no this doesn't only apply to females, it works for anyone.
Better be careful with what you say around _____, they've got a serious case of P.K.B.S.
used to describe losers from "The Valley" or some other such place. they wear clothes from the G.A.P. while rolling around in BMWs listening to Eminem.
"Hey, finish that beer so we can go punk those p.s.k.s and take their bitches."