Perhaps the most famous line from Cpt. Jean-Luc Picard in the STAR TREK: TNG episode "Datalore". Picard tells Wesley to shut up after he tries to warn the crew that they were actually talking to Lore, Data's evil twin. This also works when someone won't stop whining about something.
v. To snap and finally tell off the people in your workplace, school, or other parts of your daily life, in the most dramatic fashion possible. May involve screaming "SHUT THE FUCK UP!" without warning and at the top of your lungs, delivering a tirade amongst your equals, and/or smashing a back-stabbing, good-for-nothing best friend's face with an ergonomic keyboard
Guy: Dude, my boss got on my case again yesterday, and I finally Wesley Gibsoned out of there once and for all.
Friend: Wow, I bet you really let them have it, huh?
Wesley Gibson: "I understand. Junior high must have been kind of tough, but it doesn't give you the right to treat your workers like horse shit, Janice. I know we laugh at you, Janice. We all know you keep your stash of jelly donuts in the top drawer of your desk. And I want you to know that if you weren't such a bitch, we'd feel sorry for you. I do feel sorry for you. But as it stands, the way you behave... I feel I can speak for the entire office when I tell you... Go fuck yourself."