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up in: (adverb) location of with which an object is placed and an action is occuring.
"Don't be puttin my name up in yo mouth!"
up in by shortbus January 5, 2004
The act of violating one's personal space, often used with the verb "nosing"
My mom totally found my stash when she was nosing up in my room, now I'm grounded for life + forever. alternately That chick I met was hot, but then she started nosing all up in my sex life, and I don't want her to know that Jennie might have gonorrhea, so I slap her upside the head and she don't be nosin' up in anything.
up in by Jimbo December 1, 2003
when a dick goes in your heiny
My boyfriend tried an up in.
up in by Vagina November 4, 2003

Up in the Piece 

To be situated in or upon a particular destitation or area, usually a confined space with specific connotations.

Also may be used to indicate/intimate body-size or surface area of a person.
Is there carrot cake up in this piece?

Her big ass was all up in the piece
Up in the Piece by VirginiaP4 April 7, 2009

up in this bitch 

another way of saying "up in here." Only it's a way better way of saying it because peoples know you mean bizness cuz of the expletive.
Damn dude, I gots the munchies. We need some brownies up in this bitch.

up in the air 

adj. Something which is tentative, iffy, uncertain, unresolved, or otherwise not definitive. An unsettled matter.
After George had that cold, the trip to the opera was completely up in the air.
up in the air by united spammers January 13, 2011