omgdiss Share definition Flag And acronym used by stoners when they have smoked an extensive amount of marijuana; the acronym stands for: "Oh My God Dude I'm So Stoned." Hahahahahaha yeah bro. omgdiss omgdiss by Too Hgih May 22, 2010 0 0 Get merch Get the omgdiss mug. Buy Now — $32.95 See more merch