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Chatroom shorthand for, "oh my god I'm so sorry."
Leah: My boyfriend dumped me.
Bruce: OMGISS!
pronounciation: o-m-g-i-s-s (or just omgiss)
derivative: omg, omfug
omgiss by rosekiss February 6, 2009
Related Words

omgdisbitch 

A hilarious tumblr blog owned by a beautiful and talented girl with the initials E.S.
Are you following omgdisbitch on tumblr?
Omgdisbitch is perfect!
omgdisbitch by DeeAna July 26, 2014

omgmissile 

When you're playing a war game, and you suddenly are hit, it is common to say "omgmissile". This became adapted just to be said in general online chat, and is often shortened to omgmsl, which is mistaken for omgmisled.
John: omgmissile, I wus hit!
Paul: omgmsl, UR such a 'tard..
omgmissile by sugarrmouse October 18, 2008