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four loco 

Elixir, beautiful nectar of life that increases one's capacity to talk to beautiful women exponentially.

Side effects include: disdain for sobriety , chronic erosion of morals, inability to speak, partial temporary amnesia, complete aversion to anything resembling work, permanent irreversible inability to be shy around beautiful women, brain damage, and misspelling of simple words
I drank so much four loco I couldn't use my hands.

I was having so much craic on that four loco, I never realised I had spelt it wrong for 2 months.

Four loco? Sure that's morning drink!
four loco by The craic police September 12, 2013
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The fourloco effect 

When you drink until you drop, but you don’t drop because you’re zooted off uppers, so you’re you just drink, and drink, and drink,
“I got alcohol poisoning once from the fourloco effect. If you’re going to go through an entire bottle of Bacardi and an 8ball in one night, invite more than 2 people.”