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The Sophies 

Sickness that sends excrement exploding from both ends simultaneously requiring one to make a most painful choice (roughly equal in difficulty to Sophie's Choice) over what will go into the toilet and what will have to be cleaned off the floor. One will often get The Sophies after a long night of drinking. The only known cure is a sink close enough to lean against and vomit into while crapping in the toilet.
You better find another bathroom 'cause John drank an entire bottle of vodka last night and had a wicked case of The Sophies.
The Sophies by Craptastrophy October 14, 2011
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The Sophie Syndrome 

When you're fucking ill every fucking week, sometimes all year around...
Friend 1: hey, are you ill bro?
Friend 2: yeah bro, i got The Sophie Syndrome
Sophie: ffs, fuck you guys

The Sophie 

"Her favorite food was mashed potatoes, so we did The Sophie."
The Sophie by ncfurifwek June 3, 2014

The Sophie Syndrome 

When you're fucking ill every fucking week, sometimes all year around...
Friend 1: hey, are you ill bro?
Friend 2: yeah bro, I got The Sophie Syndrome

The Sophie Effect 

Being the universal It Girl. People yearn just to breath the same air you do. You are literally being treated like a prophet.
Bali: Did you see that? Someone just dropped to their knees and started screaming crying after she rejected them.
Lynda: Yeah, it’s The Sophie Effect. 🤍
The Sophie Effect by szoffer September 9, 2023

the green sophes

The coolest band in the history of the world. Period.
the green sophes by green323 December 13, 2008

sophie is the best 

Sophie is just the best person ever she is really pretty and has LOADS of friends.