Sis 

Term used among gay bottoms that have a double meaning of both “sister” and or “sissy” but used with endearment .

Hey sis how was your night …

Sis it was long and hard

Sis by LuiLifestyle April 4, 2022

sis 

the word that avery got sibling-zoned by

avery: he called me sis. i've literally lost sleep over this. what does it mean :(
noah: you just got sibling-zoned

sis by nopo2 November 6, 2022

Sis 

1. Short for “sister”
2. A term girls who downvote posts on UrbanDictionary call each other because guys call each other “bro” and they want to try to be just like them because “eQuAlItY”

“Hey sis.”
Ew don’t call me that, we’ve known each other for like 3 days.

Sis by TheAlwaysCorrect1 January 12, 2023

sis 

This word is used on a girl usually by another girl if they are friends or know each other. This word can also be used in an offensive way. (this word is aave so don’t use it the wrong way if u white unless u wanna get clowned)

*walks into the room*
friend: “hey sis

“Sis thinks she’s all that”

sis by Dalingoudntkno614 August 10, 2023

sis 

the girl version of “bro”, used as a form of address.

A (girl): wassup bro
B (boy): wassup sis

sis by MosesC November 7, 2023

sis 

a stinky poo

I am so sis
Wait you're a stinky poo?

sis by oiasdhyf dss December 1, 2023

Sis Out

A night to chill with the ladies, watch chick flicks, drink sparkling grape juice, laugh obnoxiously, and embrace all things feminist. What happens between gals during this time, stays with the gals. Forget the misters, and hang with the sistas!

Sis out tonight, ladies? Heck yes.

Sis Out by FlasheyAshey December 27, 2011