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It is a mysterious abbreviation that is apparently very offensive because everytime you ask they'll tell you to shut the fuck up. So it is essential to avoid asking for the meaning of the abbreviation.
"Oi Johnny what does stfu mean?"
"Shut the fuck up, mom"
stfu by jugojugojugo April 12, 2020
Abbreviation for SHUT THE FUCK UP !!!!!!!! Damn I shouldn’t have to explain this to y’all. You should already know this shit Dumb as fuck. I’m kidding sorry bout that shit man
Dude one: hey have you seen me do--
LittleLaurie: STFU
STFU by LittleLaurie May 6, 2020
A song only true fans of pink guy can apreciate and means shut the f*ck up
"Stfu family,teacher,therapist,sleep paralysis demon,Karen and god"
means you should shut the fuck up, or more simpler, be quiet.
Olivia: "hey guys guess what i go-"
jay: "stfu you goofy ass hoe no one cares the fuck🤣🤣🤣🤣🤣🤣"
stfu by fresh tbh January 23, 2022
Shut The Fuck Up.

An acronym that will get you reported and punished in World of Warcraft, because Blizzard is fascist.
Nub Rogue in BG chat: OMGWTF YOU GUYS SUCK!
Annoyed Player: Dude, stfu and play.
stfu by koalaroo March 5, 2008
a widely-used acronym for "shut the fuck up"
STFU by Phishr August 12, 2005