It is another word for a blunt, which is a cigar that is hollowed out and filled with cannabis. It is in reference to the myth of Medusa, where anyone that saw Medusa's face would be turned to stone. The blunt itself will get the person smoking it high, or "stoned".
A male sex toy where six fleshlights are strung together from a mannequin's head each with a different sensation. The last person to finish must guzzle the contents.
Hey man do you want to hang out tonight? We can do Medusa's head.
Nah last time I hung with Medusa I had to clean up.