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To cause to explode, usually using dynamite/TNT, grenades, etc.

A cure for everything.
Harry: Ron, I think my scar's hurting again.
Ron: Oh jolly good Harry, now we can blow it up.
blow up by [ - stacys mom - ] October 29, 2003
To force someone, often political prisoner to drink a cup of gasoline and then stabing them in the chest with a red hot blade on a 15-foot pole causing them to explode violently.
Person 1: Did you hear about when Vladimir Putin got some journalist to blow up because of what he wrote.
Person 2: Ya, that shit was on the news.
Blow up by BigBoySatin December 9, 2019
Sporting term, to become tired
About 10 minutes into the game he began to blow up quite badly.
blow up by D Sizzle June 23, 2004
To overreact in an angry way
"Why did you blow up when I tried to break up with you"
"Because you were being unfair"
Blow up by Truth457 May 17, 2017
What happens in space when you give a blow job.
When she lifted her head off his cock as he was about to cum causing it to blow up!
Blow up by Elizabeth N. October 28, 2018
To light up or/and smoke a joint, blunt, spliff, etc
Yo man I got some fresh Gorilla Glue let's blow that shit up!

This party is wack af bruh lets go out and blow up some.

Come here boy, I'll let you blow this jay up.

He said he bringing some fat ass joints for all of us to blow it up after classes.
blow up by Crank White July 13, 2022