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A derogatory word, used for someone who is involved in idiocy or mishaps. Closely related to the word lousy but referring to self or others.

"I just dropped the TV and broke it. I'm such a louse."
"He is always so clumsy, what a louse."
Louse by trko January 31, 2009
Irish, particularly Dublin, slang that means someone who ruins things, or just a general bollix.
He loused that up!
He's a feckin' louser!
louser by fromireland October 29, 2007
Used to describe someone who causes a team to lose while playing a game. Someone who you can never win a game with no matter how hard you carry.
Person I: I can’t believe you made us lose that round Karen.. you’re literally the worst. You better have been trolling and not an actual louser.
Louser by coolerthanrat2and3 April 21, 2019

Crab Louse 

Song performed by "Lords of Acid"
Dude, Lords of Acid played Crab Louse at their concert last night
Crab Louse by bjmoore October 23, 2008
Someone who drinks excessively, and who is drunk most of the time.
"Jen drinks a lot, she's such a louse!"
louse by JKix June 15, 2005
Irish slang, mainly in Dublin, commonly used in private secondary schools, and in the youth.

someone with red hair and freckles
an annoyance
the singular form of lice, many louses
often referred to as ginger, ginger pubes, or "OI YOU! GINGER!"

OI YOU! LOUSE! shut the fuck up you freckly little shit!
Louse by RobKickAss April 14, 2006