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A drug used to sedate women, or to make them incoherent to prevent unwanted sexual acts.
1)You gave that poor girl a Cosby didn't you?
1A) Yup, and she was out like a light.
Cosby by UnknownIgnorance December 2, 2014
A multi colored sweater.

Stemming from the days of the Cosby show, in which the main character, Heathcliff Huxtable, played by Bill Cosby, constantly wears bright, multi colored sweaters.
Tom came into the office wearing a colorful sweater.

Mohan exclaimed "Damn Tom, nice Cosby!"
Cosby by Chips August 11, 2004
A sexual senario, its background pertaining to the fact that the african american comedian Bill Cosby used to advertise jello. "A Cosby" is where a girl sucks a man's dick, with jello in her mouth as well.
"Dude your girlfriend gave me a cosby yesterday"
Cosby by BloodMatrix February 20, 2005
The act of slipping something into an unsuspecting woman's drink and then proceed to fuck her silly.
Dat bitch Felicia just got cosby'd
I hate her so much that I'm going to Cosby her at the party tonight.
Cosby by Djjglitz December 4, 2014
Used online in the Blizzard game "Starcraft" when a nuke is used to kill mass units.
{after nuking 30 zerg units} "Holy shit, that was a cosby!"
Cosby by Murdock November 24, 2004
"I ain't one of the Cosby's , I aint go to Hillman" Kanye West
cosby by Jay37 February 26, 2008