mister-sister 

Someone of the male species, that wants and or appears to look like a female.A male that is very feminine, also known as a "shemale"

That gay guy looks like mister sister

mister-sister by Nicki November 10, 2003

mister sister 

a transgendered person

Chet: That girl looks awfully masculine
John: Haha Chet, that isn't a girl, that's a mister sister
Chet: A what?
John: A mister sister. A shemale. A tranny. You gettin' it?

mister sister by SHMOSEPH May 8, 2013

mister sister 

A drag queen.
Origin: "Will and Grace"

Don't mess with that mister sister, or you'll end up looking like a Cher barbie doll gone bad.

mister sister by asdfghjkl September 25, 2006

UR SISTER MISTER 

The most destructive comeback to date. Only to be used in very dire situations. (Can be used if target doesn't have a sister)

Joe: ur mom gay
Tim: no u
Joe: UR DAD LESBIAN

Tim: UR GRANNY TRANNY
Joe: UR PAPPY TRAPPY
Tim: UR SISTER MISTER
*At this point time ceases to exist. The very fabric of the universe has be torn to shreds, the entire 3rd dimension is incinerated and all life on earth ceases to exist*

UR SISTER MISTER by lazer unicorn March 14, 2018

Slay what you wanna slay and let the slay slout. SLAY SOUL SISTER, SLAY MY SISTER MISTER. 

The worlds best song, DUH!

IF YOU DONT KNOW IT GO AWAY!

-UWU MASTER

Person: How's your day?
You: Slay what you wanna slay and let the slay slout. SLAY SOUL SISTER, SLAY MY SISTER MISTER.

Slay what you wanna slay and let the slay slout. SLAY SOUL SISTER, SLAY MY SISTER MISTER. by UWU SENPAI MASTER May 16, 2022

Your Sister Mister 

An insult that has the same effect as your mom gay.

Friend 1: Your Mum Gay
Friend 2: Your Sister Mister
Friend 1: *Dies From the Insult*

Your Sister Mister by Nickable May 12, 2018

Ur sister mister 

The worst possible insult ever in the entire world apart from your granny tranny

"Your Granny Tranny lol!"
"Ha! Your sister mister"
*implodes*

Ur sister mister by Damoxd March 22, 2018