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I don't want to ruin our friendship 

Can I just stick it in a little? I'm so horny!

I'd let you, but I don't want to ruin our friendship.

I don't want to ruin our friendship 

What a girl says when you have been friends with her for a while, but does not want to take the next step and become your girlfriend. Basically those works are a huge kick in the balls.
Girl: "We could start going out, but I don't want to ruin our friendship."

Guy: "OK, I understand completely."

Guy's thoughts: "GOD DAMNIT!!!!"

i wanna ruin our friendship

When you want to move past a friendship and into an actual relationship.
Larry I think I have feelings for you, I wanna ruin our friendship.

I don't want to ruin our friendship 

Polite refusal to engage in sexual activity with a member of the opposite (hell, this is the new millenium, or the SAME) sex.
Amanda turned down Melissa's proposition for a dirty weekend, saying "I don't want to ruin our friendship." Then she deleted Melissa from her Outlook contacts, her cell phone SIM chip and changed her phone number.

I don't want to ruin our friendship 

In other words it means I don't want to go out with you, but I still want to be friends. Often used to let someone down gently.
I don't think we ought to date, I don't want to ruin our friendship

I don't want to ruin our friendship 

Two meanings::
(1) What you say to a friend (female/male) when you don't wanna hook up.

(2) What you say to a friend(female/male) when you do wanna hook up but dont wanna to seem so eager, when in all reality you are.
(1) "I've always liked you, but I don't want to ruin our friendship"