prairie vole Share definition Flag A Prairie Vole is a woman who after one good encounter wants to commit to monogamy because of the hormones released with orgasm. Awe, shit, now she's acting like a Prairie Vole, wanting me to see only her! prairie vole by amesababe June 23, 2010 0 0 Get merch Get the prairie vole mug. Buy Now — $32.95 See more merch