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When your insides feel like they just barfed on themselves.
"Hey I feel like I have to take a big dump, but I can't, so I must have gut rot."
gut rot by Wessie Jittaker August 1, 2007
A catchall term for heartburn, acid reflux, ulcers, and other things where your stomach feels like it's digesting itself. Since for the most part, you take the same pills for them, there's rarely a need to differentiate in casual conversation.
"Oh man, I've got some killer gut rot, anyone got some Rolaids?" "Here, take a Zantac, it'll work better. And maybe you should stop working 80 hour weeks and eating garbage?"
gut rot by roxyhead August 26, 2011
A very serious stomach ache that is the result of bad food or prior malt liquor consumption that occurs just before a sloppy case shitting.
Gary: Hey Crid why do you look like someone kicked you in the balls?

Crid: Because, I have Gut Rot from Terry's tacos I ate yesterday.
Gut Rot by Cridis shortstacked December 30, 2007
Hapens after you drink too much beer.
The next morning.
"Ouch, my stomach hurts." said sally
well, explained gary "If you didn't drink all that Colt 45 you wouldn't have gut rot."
Gut rot by Caroline May 31, 2003
The thing you get after eating at Taco Bell
Lesley and Elena are walking down Yonge Street to grab a bite. Lesley points at a resturant and asks Elena if she has ever been there. Elena says she has, and Lesley says "it gives me gut rot".
gut rot by Kookie Kutter May 22, 2009
A painful sensation in the "gut", happens most frequently to those addicted to coffee and cola.
After the third Venti (TM) Americano (TM), Todd doubled over and clutched his stomach. "Gut rot!" he hissed.
gut rot by 0x15 January 15, 2004