Noun. Mouth, i.e. the orifice one ought to be using for eating cake rather than talking shit. From the British slang cakehold, a vulgarity in the 50s or 60s. Now recognized as a very juvenile colloquialism. See also pie-hole.
A quote made famous for its use in season 1 of Supernatural. Implies that the driver of a vehicle chooses what music they and the passengers will listen to while whoever is riding shotgun must stay quiet.
Sam: You gotta update your music collection. Black Sabbath? Motorhead? Metallica? It's the greatest hits of mullet rock.
Dean: Well, house rules Sammy. Driver picks the music, shotgun shuts his cakehole