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Meaning to shut your fucking mouth because you don't deserve to talk because your a fucking bitch that doesn't have a live because they keep talking like a ho.
Shuffup by Heebummie October 21, 2008
Related Words

Shuffuck 

A phenomenon that takes place in a club or party. The phenomenon starts when shuffle music, for example "Party Rock", gets played and then everyone in the vicinity with the inability to shuffle proceeds to kick madly everywhere, causing embarrassment, pain and emotional hilarity.
"Dude, what happened to your leg?"
"I went to that club last night, it was a total shuffuck"

"That guy is a shuffucker"
"How do you know?"
"His shoe hit my face"
Shuffuck by Banzboy02 December 20, 2011
The ultimate form of being owned. To be owned greatly.
Tim's girl ran off with a 7-year-old. He has been shffpwnd.
shuffpwn by cool July 24, 2004
Instead of saying 'Oh well' or 'doesn't matter' you might say 'SHUFFU'
Person 1: Oh no! I lost my bracelet!

Person 2: Shuffu.
shuffu by lda1411 April 11, 2009
Susie went on and on about her new car; I finally told her to shufup!
Shufup by JimShoe September 1, 2009
1. v. To harm, hurt, or insult someone or something; to win.
2. adj. Distasteful or bad in some way.
1. John shuffpwnd Marcus' guitar with a sledgehammer.
2. The band played a shuffpwn set.
shuffpwn by schl0ng August 28, 2004