Ayo is when people make unfunny sexual joke in class or when they find something suspicious they scream that word all the time
Magic school bus episode:
Girl: gets says something is big
Man1: that kinda sus lol
Man2:hehe Girl: gets covered in white stuff (yes its real)
Man1:AYO AYO THAT KINDA SUS
Man2: hahahaha
Man3: stop being inappropriate