Much the same as "living shit", "the bejesus", or "the devil"; for example, when you're beating the living shit out of something.
Andrew went on the rampage at work this morning when the copier spit toner all over him -- he literally beat the living tweedle out of the poor, defenseless, helpless copy machine!
Topher was so fond of his new R/C piloting skills; he flew the living tweedle out of his Cessna 182 R/C airplane at the park over the weekend.
A Texas heavy metal band that was popular in the 80s and consisted of Donny Hart on vocals, Damon Duperre on guitar, Scott Wood on bass guitar and Lance Williams on drums. Boss Tweed has been credited as the origional heavy metal band from Texas opening up the doors for bands like Pantera, Rigor Mortis, and Drowning Pool.