Frantic and compuslive behaviour often associated with methamphetamine abuse (crank). People who regularly abuse crank may find themselves unable to stop a particular random activity like searching drawers, having sex, or putting things apart. This is called tweaking.
"Oh man last night was awesome, I was tweaking and fucked my girlfriend for 6 hours straight..."
High on meth/crank. See also "Smebbin".
I was tweaking so hard I couldn't see straight.
To describe someone that is out of thier mind or making a mistake.
"Ohh did I say 6:00 o'clock? I ment 5:00, I'm tweaking!"
1. To be under the effects of amphetamines, esp. crystal methamphetamine hydrochloride.
2. To be nervous or worried about something, esp. the presence of law-enforcement personnel.
1. Dude I took a fat hit of some dank ice
and I'm tweaking balls!
2. Dude I got pulled over with an o in my glove compartment and I was tweaking balls!
To do crack or act like doing crack/cocaine.
Most of the time used in a question
"Gave who some dam money? I aint gave no nobody no damn money girl! IS YOU TWEAKING!?" By R-kelly Real Talk
Dude, you are totally tweaking.
Having a good time
It can be used as a substitute for "drinking", "partying", etc
Paul sure is tweaking
Oh, those fiends be tweaking tonight!