Top Definition
Frantic and compuslive behaviour often associated with methamphetamine abuse (crank). People who regularly abuse crank may find themselves unable to stop a particular random activity like searching drawers, having sex, or putting things apart. This is called tweaking.
"Oh man last night was awesome, I was tweaking and fucked my girlfriend for 6 hours straight..."
by RoOophy July 08, 2004
10 more definitions
High on meth/crank. See also "Smebbin".
I was tweaking so hard I couldn't see straight.
by KOW October 11, 2002
To describe someone that is out of thier mind or making a mistake.
"Ohh did I say 6:00 o'clock? I ment 5:00, I'm tweaking!"
by Ashleysophia December 05, 2007
1. To be under the effects of amphetamines, esp. crystal methamphetamine hydrochloride.

2. To be nervous or worried about something, esp. the presence of law-enforcement personnel.
1. Dude I took a fat hit of some dank ice and I'm tweaking balls!

2. Dude I got pulled over with an o in my glove compartment and I was tweaking balls!
by Bri90 January 28, 2010
acting stupid or any annoying behavior
ms. neiman keep tweaking.... getting on my nervs
by fmoi igb_kvng January 14, 2015
To dance in a particular way referencing Bobbie Shmurda's song "hot nigga".
She tweaking hoe!
by Bholmes_xo November 26, 2014
To do crack or act like doing crack/cocaine.

Most of the time used in a question
"Gave who some dam money? I aint gave no nobody no damn money girl! IS YOU TWEAKING!?" By R-kelly Real Talk
by HondaKiller2TGR June 18, 2008

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