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1. tweaking
Frantic and compuslive behaviour often associated with methamphetamine abuse (crank). People who regularly abuse crank may find themselves unable to stop a particular random activity like searching drawers, having sex, or putting things apart. This is called tweaking.
"Oh man last night was awesome, I was tweaking and fucked my girlfriend for 6 hours straight..."
by RoOophy Jul 8, 2004 add a video
2. tweaking
High on meth/crank. See also "Smebbin".
I was tweaking so hard I couldn't see straight.
by KOW Oct 11, 2002 add a video
3. Tweaking
1. To be under the effects of amphetamines, esp. crystal methamphetamine hydrochloride.

2. To be nervous or worried about something, esp. the presence of law-enforcement personnel.
1. Dude I took a fat hit of some dank ice and I'm tweaking balls!

2. Dude I got pulled over with an o in my glove compartment and I was tweaking balls!
4. tweaking
To describe someone that is out of thier mind or making a mistake.
"Ohh did I say 6:00 o'clock? I ment 5:00, I'm tweaking!"
5. Tweaking
To do crack or act like doing crack/cocaine.

Most of the time used in a question
"Gave who some dam money? I aint gave no nobody no damn money girl! IS YOU TWEAKING!?" By R-kelly Real Talk
6. Tweaking
another word for banging
We were tweaking last night and the rubber broke.
7. tweaking
1. High on DXM
2. High on speed
Dude, you are totally tweaking.
by Epigone Jul 1, 2003 add a video
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