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1.
Frantic and compuslive behaviour often associated with methamphetamine abuse (crank). People who regularly abuse crank may find themselves unable to stop a particular random activity like searching drawers, having sex, or putting things apart. This is called tweaking.
"Oh man last night was awesome, I was tweaking and fucked my girlfriend for 6 hours straight..."
by RoOophy July 08, 2004
653 321
 
2.
High on meth/crank. See also "Smebbin".
I was tweaking so hard I couldn't see straight.
by KOW October 11, 2002
320 247
 
3.
To describe someone that is out of thier mind or making a mistake.
"Ohh did I say 6:00 o'clock? I ment 5:00, I'm tweaking!"
by Ashleysophia December 05, 2007
282 252
 
4.
1. To be under the effects of amphetamines, esp. crystal methamphetamine hydrochloride.

2. To be nervous or worried about something, esp. the presence of law-enforcement personnel.
1. Dude I took a fat hit of some dank ice and I'm tweaking balls!

2. Dude I got pulled over with an o in my glove compartment and I was tweaking balls!
by Bri90 January 28, 2010
193 184
 
5.
To do crack or act like doing crack/cocaine.

Most of the time used in a question
"Gave who some dam money? I aint gave no nobody no damn money girl! IS YOU TWEAKING!?" By R-kelly Real Talk
by HondaKiller2TGR June 18, 2008
82 162
 
6.
1. High on DXM
2. High on speed
Dude, you are totally tweaking.
by Epigone July 01, 2003
105 185
 
7.
another word for banging
We were tweaking last night and the rubber broke.
by Brownhole24 October 07, 2010
64 160