Mainly used in Philadelphia, A Tweaker is a female who gets around! A whore, smut, slut, hoe, or trick. "Tweak" can also be used in it's place, as well as "Tweaking"
Yo bul?

"Wassup with you bul?"

Shit!...whats up with Kaneisha and them?

"I don't know.....but I def heard her squad is some tweakers!"

Oh yea?.....they tweakin?

"That's What I Heard!"
by mickey futuristic February 18, 2010
fuckin pathetic indivisual who wants to waste their time being more white trash than a fat nappy hoe whos trailer is parker outside of wal-mart. Someone who gets spun all the time, fucks alot because it makes them horny, then pisses and whines and cries when they get felony posession for a teener. They are all fucktards and I hate them. Speed is retarded. Tweakers are drug addicts so stupid that they'll smoke ice with fermaldihyde in it. Tweakers as females are usually nappy hoes. They always have tattoos on their back pointing to their ass we call this "the target". Those who stop doing tweaker often develop baby tweaker fat and get all fat ugly and nasty. This is called white trash : stage two! (the walmart shoppers who eat at mcdonalds while they are there). Tweakers are characterized by their unsociability, the way they are total jackasses, and the way they always seem to have herpes. They are usually ugly fucktards and only want to chill with you if you can get them spun because they are pathetic lowlifes. And for some reason, they get horny as fuck but haven't discovered the modern invention called the condom. They are fond of multiplying and breeding little future white trash tweakers. Often they will have up to 5 kids, but give one or two away. These kids would have better destinies if they were growing up as autistic carnies in the midwest. Ironically, many tweakers go on to become carnies. They can be spotted easily by their lack of teeth and body fat. Did i mention they are usually dickheads? Another way to spot a tweaker is to go to DHS and find the skinniest woman with the most children applying for TANIF. Section 8 is also a haven. The most common excuse by the tweaker, is that somebody made them do it.
Is that tweaker hoe gonna be at our wedding? Make sure to hide the ice sculpture of David. Bitch'll fuck anything with a dick made of ice
by fuck88 October 25, 2006
1) A speed, or meth addict who has assumed the role of the drug, in other words, they lost their personality to the drug.
2) An ex- deadhead or hippie who has fried their brain and is now living in the small, paranoid world of warped memories of a mundane adolescence. They communicate by spreading urban legends as "amazing" inspirational stories that align with their perception of reality.
3) A stupid, spastic teen (or adult, but less common) that display ignorance and naivety with every action.
I was walking through the Haight the other day and was surrounded by tweakers.

I went to my high school reunion and the tweakers were still messed up in the head.
by stv October 05, 2004
Philadelphia's (Philly's) own slut.
The word "tweaker" is often used to describe a girl with sloppy, slut-like attributes, and is known for getting with a lot of guys. A tweak is a nicer way of calling a female a whore, and or slut, and a tweaker may get with more popular, or famous guys. The word "tweak" is also used and is just a shorter version of the word "tweaker".
Malik: Yo, did you see Vanessa with Jamal last night? Yeah, she was giving him head in the back of the party, and everyone saw...
Kyle: Yeah, I know, that girl is such a tweaker.
Malik: Smh what a tweak.
by Olive_Garden69 October 30, 2011
Tweaker: Boy/Girl tht go around fuckin everybody . Gettin passed around the whole team or city/place
Boy: there go tht tweaker over there
Girl: How She A Tweak
Boy: The Whole Team Was In Tht Bitch
Girl: Smh Fuckin Whore
by TweeterTweet December 20, 2010
Someone who Messes around with more than one person.
Christina had sex 5 Guys Last Night. She is Such A Tweaker!
by Mizzjas1802 October 13, 2010
a whore, a promiscuous female who engages in sexual activity with a lot of people who they have no relationship with.
"man, she'll let anybody hit, she a tweaker."
by k_milly May 10, 2009
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