a female that is a whore or has multiple sex partners. Originated in Philly; used in Philly and parts of Delaware.
Jon-ayo she a tweaker. da whole crew hit dat!

or
Jay-yo why did u and yo girl break up? she was fine!
Jon-yeah she was fine but she was a tweaker
Jay-aw man!
by lilmamapullin April 01, 2010

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basically an hore or slut a female who has sex with many guys
yo you know dat girl down da street?

yea man she a whole tweaker
by dabullty December 09, 2009

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Slut,whore,yooker,bobblehead
Your girl is a tweaker everyone bust her ass
by jkgggk September 16, 2009

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1. A person that's like a hoe

2. Some one who will talk to alot of females/males at once

3. Some one who's addicted to drugs
"Yo, you a tweaker for real"

"shut up tweaker!!"
by Philly Girl_14 June 19, 2009

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Someone with a methamphetamine who is usually a theif.
That fucking tweaker stole my lighter
by Dustin Hubiak June 01, 2007

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1. A person who customizes an operating system, a.k.a. MS Windows or Linux.
2. A person who speeds up their computer. See also overclocker.
1. You know Ken, always changing his settings. Such a tweaker, really.
2. Hey, that Dave guy burned out his CPU again, tweaked it too much.
by Toba September 22, 2004

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1 A thing you hold and point at the t.v. to change channels.
1 'Oh no, it's Mandelson (or other politician of choice), pass the tweaker quick.'
by Sue d'Aunim December 06, 2009

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