Mainly used in Philadelphia, A Tweaker is a female who gets around! A whore, smut, slut, hoe, or trick. "Tweak" can also be used in it's place, as well as "Tweaking"
Yo bul?

"Wassup with you bul?"

Shit!...whats up with Kaneisha and them?

"I don't know.....but I def heard her squad is some tweakers!"

Oh yea?.....they tweakin?

"That's What I Heard!"
by mickey futuristic February 18, 2010
basically an hore or slut a female who has sex with many guys
yo you know dat girl down da street?

yea man she a whole tweaker
by dabullty December 09, 2009
Someone who constantly worries about a situation and obsesses over the possible outcome of something before it happens. Someone who thinks a lot and dwells on things a lot.
I am worried about how my dress will fit, will he think I am fat?

Do you think I will get in to trouble? I am tweaking on the situation.

What will happen if the judge sends me to jail? I am a tweaker.
by kelsmaster August 09, 2009
someone who abuses methamphatamine.

usually skinny because they dont eat.
dark circles under their eyes because they dont sleep.
can harldy stand because most of their blood viens have collpased from constant injecting,

they transform themselves into a hermit-like state and keep to themselves while trying to have a normal life.
kid 1: i think that jon is using meth.
Kid2: yeah i definatly think he is a tweaker
by lovebabefor April 08, 2009
1) A speed, or meth addict who has assumed the role of the drug, in other words, they lost their personality to the drug.
2) An ex- deadhead or hippie who has fried their brain and is now living in the small, paranoid world of warped memories of a mundane adolescence. They communicate by spreading urban legends as "amazing" inspirational stories that align with their perception of reality.
3) A stupid, spastic teen (or adult, but less common) that display ignorance and naivety with every action.
I was walking through the Haight the other day and was surrounded by tweakers.

I went to my high school reunion and the tweakers were still messed up in the head.
by stv October 05, 2004
Someone who likes to adjust or fine-tune things; a person who makes small changes to an existing object in order to make it better or to suit one’s preferences
Tessa is known as the Tweaker in her social circle for her knack of turning old fabrics into fashion-forward apparels.
by fln September 23, 2013
A people who uses the drug methamphetamine. A low life piece of shit. Someone who will steal from you in order to score meth. Zombie like
I was watching the video "tweakers" by skinny mumbles on YouTube.

The tweaker beater mafia is coming to town to get rid of our cities meth problem.
by DirtyGiggles February 27, 2012

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