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29.
a female that is a whore or has multiple sex partners. Originated in Philly; used in Philly and parts of Delaware.
Jon-ayo she a tweaker. da whole crew hit dat!

or
Jay-yo why did u and yo girl break up? she was fine!
Jon-yeah she was fine but she was a tweaker
Jay-aw man!
by lilmamapullin April 01, 2010
 
30.
A female who has sex with a whole lot of guys and has no care of doing so.
She was at my house yesterday and now she's with my homie, I told him she was a tweaker.
by Geminibul23 January 19, 2011
 
31.
Tweaker: Boy/Girl tht go around fuckin everybody . Gettin passed around the whole team or city/place
Boy: there go tht tweaker over there
Girl: How She A Tweak
Boy: The Whole Team Was In Tht Bitch
Girl: Smh Fuckin Whore
by TweeterTweet December 20, 2010
 
32.
A word used popularly in Philadelphia, Pa to describe female dogs who get “smutted” around by a group of men. The men are either friends, cousins or even siblings maybe complete strangers but that's rare with Tweaks. Tweakers are often exposed on the Tweaker List page via Facebook. Tweakers are not aware that they’re tweakers, until they appear on the Tweaker List. However, 99.9% are still in denial after being featured on every list. You can always find a Tweaker on Broad & Olney, King of Prussia, and Franklin Mills. They're in there like swimwear.
Girl: I'm not a tweak, I'm 15 years old and I let 5 guys hit.
I only sucked 14 dicks this year. Yes, I'm on the tweaker page, but these girls just hating on me because I had sexual intercourse with their boyfriends.

Boy: Your the true definition of a tweaker.
by Never Lying September 13, 2010
 
33.
A Noun. A GIRL OR BOYTHAT IS KNOWN FOR SLEEPING WITH OR GIVES ORAL SEX TO PRACTICALLY THE WHOLE NEIGHBORHOOD.

A Noun. A GIRL OR BOY THAT IS KNOWN FOR SLEEPING WITH OR GIVES ORAL SEX TO NUMBERS OF PERSONS THROUGHOUT THE CITY.

TWEAKER IS USUALLY USED TOWARDS FEMALES, BUT IT IS NOT UNCOMMON TO USE IT TOWARD A MALE. BOYS ARE USUALLY CALLED THE "BURNING BOYS", THE EQUIVALENT OF "TWEAKER".
*SEE "BURNING" 2nd and 3rd definitions...*
JESSICA SIMPSON SLEPT WITH KIM KARDASHIAN'S BOYFRIEND REGGIE BUSH.

KIM -"Jessica slept with my boyfriend, and I heard that she slept with Common, Kanye, and Usher, and gave Ray J, and Nick Cannon oral sex,... She is a TWEAKER!!!"
by ANCIENTCHINESESECRET93 May 18, 2010
 
34.
Someone with a methamphetamine who is usually a theif.
That fucking tweaker stole my lighter
by Dustin Hubiak June 01, 2007
 
35.
fuckin pathetic indivisual who wants to waste their time being more white trash than a fat nappy hoe whos trailer is parker outside of wal-mart. Someone who gets spun all the time, fucks alot because it makes them horny, then pisses and whines and cries when they get felony posession for a teener. They are all fucktards and I hate them. Speed is retarded. Tweakers are drug addicts so stupid that they'll smoke ice with fermaldihyde in it. Tweakers as females are usually nappy hoes. They always have tattoos on their back pointing to their ass we call this "the target". Those who stop doing tweaker often develop baby tweaker fat and get all fat ugly and nasty. This is called white trash : stage two! (the walmart shoppers who eat at mcdonalds while they are there). Tweakers are characterized by their unsociability, the way they are total jackasses, and the way they always seem to have herpes. They are usually ugly fucktards and only want to chill with you if you can get them spun because they are pathetic lowlifes. And for some reason, they get horny as fuck but haven't discovered the modern invention called the condom. They are fond of multiplying and breeding little future white trash tweakers. Often they will have up to 5 kids, but give one or two away. These kids would have better destinies if they were growing up as autistic carnies in the midwest. Ironically, many tweakers go on to become carnies. They can be spotted easily by their lack of teeth and body fat. Did i mention they are usually dickheads? Another way to spot a tweaker is to go to DHS and find the skinniest woman with the most children applying for TANIF. Section 8 is also a haven. The most common excuse by the tweaker, is that somebody made them do it.
Is that tweaker hoe gonna be at our wedding? Make sure to hide the ice sculpture of David. Bitch'll fuck anything with a dick made of ice
by fuck88 October 25, 2006