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1.
Also: tweeker.

1. Person who constantly stays up cleaning, washing, organizing, powertooling, sorting or otherwise keeping themself busy doing menial tasks.
2. Someone who constantly makes slight alterations on (usually a very specific) object, i.e. computer, software, automobile, etc.
3. A compulsive liar, thief, or both.
4. A methamphetamine ("tweak"), or other form of speed, addict (who displays all of the above in an obsessive-compulsive manner).
"Tommy what are you doin' man?"
"I've been real busy sorting bolts!"
"For three days?"
"It's important though..."

What's the difference between a crackhead and a tweaker?
The crackhead will steal your shit and bounce--the tweaker will steal your shit and then help you look for it.
by A New STD February 12, 2005
 
2.
People who are paranoid, delusional, uneducated, and covered with oozing chemical scabs and ulcers due to the acute abuse of methamphetamine. They eventually eat scabs from one another that contain the meth that their body can't dispose of, just to catch a cheap thrill. MMMMM....MMMMMMMMM!!!
I called the DEA the other day on those tweakers down the street.
by running out of patience December 14, 2007
 
3.
A person that is under the influence of methamphetamines and is in the middle of three projects at the same time none of which will ever be completed.
I watched Johnny search through his bag with one hand while making something with the other,he is such a tweaker.
by Jamie Pheloney April 09, 2005
 
4.
Most commonly known as a speed/meth addict.
Less commonly known as: a female stoner.
1) "Look at Tim smokin that shit in the corner...what a tweaker."
2) "Yeah, Dori's such a tweaker!"
by Yramesor! April 14, 2004
 
5.
A person who does Crystal Meth. They talk very fast all the time. You're lucky to get a word in with a serious tweaker. They do obsessive projects ranging from, taking a TV set apart, to cleaning a tile floor with a tooth brush. Not finishing anything is common. The thing about meth is that some people have done so much, that even when they quit, they are so damaged that they retain all the characteristics of a tweaker. Ruined for life.
That dude is such a tweaker, he won't stop talking!
by Roadie Overthegate March 09, 2007
 
6.
A tweaker is someone high as fuck on crystal meth. Tweakers can have sex with their partners for days at a time. They love to clean, organize, pace, etc. Tweakers can never sit still and can only focus on one thing at a time.
That tweaker has been fucking her for 10 hours straight.
by I Love Meth October 15, 2013
 
7.
a person who is addicted to meth...(drug)
that guy smoking that shit on the chair over their is a tweaker!
by lindsey_57 July 23, 2006