Some one who does crystal aka tweak and has been up for days showing signs by talkng alot pacing around and fidgiting
"Damn Pavells A Tweaker now"
by Lisa April 09, 2004

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a person who is addicted to meth...(drug)
that guy smoking that shit on the chair over their is a tweaker!
by lindsey_57 July 23, 2006

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Methheads. Named for their twitchy, "tweaky" behavior.
"Those goddamned tweakers make me nervous to be around"
by Rokki J. Rand October 17, 2007

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A tweeker is some one who uses meth to stay up for many days.
tweaker -if you are up for 14 days you are a "two weeker".
by Lvingdedgrlinphx May 29, 2015

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An extremely overly paranoid individual usuallly high on meth or some other type of stimulant...the person is usuallyvery high strung and easily distracted by most anything.
Man, stop being a tweaker andshard farming there isn't any dope in the carpet i vaccumed..
by N9NA 9MILLAMETA August 12, 2015

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A person who uses meth and staying awake for days at a time thinks their focused on there project usually something they think they can repair but in reallity they end up breaking it so the parts end up in a box with all the other tweaker parts
He has been up for days tweaking on electronic items , and hasnt fixed any of them , all he has now is a bunch of parts, he is such a tweaker.
by Kimberly Delgado July 10, 2006

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Typically someone who smokes/snorts/does meth. Some people who have tweaker habits but don't do meth may also be referred to as a tweaker. People who are constantly touching their face, or looking around like they think someone is watching. A tweaker can typically be one of two kinds. Either very loud, weird, unusually happy about everything (or sometimes even angry) and is that "in your face" kind of person. Or that guy sitting at the back of the bus with his hood on staring at everyone nervously because he thinks they all know he's high.
A tweaker downtown today tried to sell me meth! Can you believe that?
by LiaMiaLoshia December 12, 2014

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