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8.
a person who is addicted to meth...(drug)
that guy smoking that shit on the chair over their is a tweaker!
by lindsey_57 July 23, 2006
 
9.
Some one who does crystal aka tweak and has been up for days showing signs by talkng alot pacing around and fidgiting
"Damn Pavells A Tweaker now"
by Lisa April 09, 2004
 
10.
Methheads. Named for their twitchy, "tweaky" behavior.
"Those goddamned tweakers make me nervous to be around"
by Rokki J. Rand October 17, 2007
 
11.
Mainly used in Philadelphia, A Tweaker is a female who gets around! A whore, smut, slut, hoe, or trick. "Tweak" can also be used in it's place, as well as "Tweaking"
Yo bul?

"Wassup with you bul?"

Shit!...whats up with Kaneisha and them?

"I don't know.....but I def heard her squad is some tweakers!"

Oh yea?.....they tweakin?

"That's What I Heard!"
by mickey futuristic February 18, 2010
 
12.
Originated in Philadelphia

A female that has sex with a lot of males, possibly just to become popular of doing it because she feels like it.
If you let a boy and his friends have sex with you are considered a tweaker.
by briight April 06, 2010
 
13.
a tweaker is someone who has been doing Crystal Meth for a while and feens for it and is always twitching. Some one who is an addict for Meth.
L. - damn nigga YU're girl is a tweaker aint she?
P. - Ya im going to drop that bitch soon, she fucking up and be doing too much for the dopey
L. - oh, yah how much, give her my number in that case.
by baddxbxtchxdopey August 07, 2010
 
14.
basically an hore or slut a female who has sex with many guys
yo you know dat girl down da street?

yea man she a whole tweaker
by dabullty December 09, 2009