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8.
A person that can't stay still and is constantly occupying themselves with meaningless activities which will never be be completed.
Tim is working on one of his tweaker projects in the garage.
by Jamie Pheloney April 09, 2005
267 231
 
9.
Some one who does crystal aka tweak and has been up for days showing signs by talkng alot pacing around and fidgiting
"Damn Pavells A Tweaker now"
by Lisa April 09, 2004
192 156
 
10.
Methheads. Named for their twitchy, "tweaky" behavior.
"Those goddamned tweakers make me nervous to be around"
by Rokki J. Rand October 17, 2007
86 63
 
11.
Mainly used in Philadelphia, A Tweaker is a female who gets around! A whore, smut, slut, hoe, or trick. "Tweak" can also be used in it's place, as well as "Tweaking"
Yo bul?

"Wassup with you bul?"

Shit!...whats up with Kaneisha and them?

"I don't know.....but I def heard her squad is some tweakers!"

Oh yea?.....they tweakin?

"That's What I Heard!"
by mickey futuristic February 18, 2010
126 127
 
12.
Originated in Philadelphia

A female that has sex with a lot of males, possibly just to become popular of doing it because she feels like it.
If you let a boy and his friends have sex with you are considered a tweaker.
by briight April 06, 2010
4 7
 
13.
a tweaker is someone who has been doing Crystal Meth for a while and feens for it and is always twitching. Some one who is an addict for Meth.
L. - damn nigga YU're girl is a tweaker aint she?
P. - Ya im going to drop that bitch soon, she fucking up and be doing too much for the dopey
L. - oh, yah how much, give her my number in that case.
by baddxbxtchxdopey August 07, 2010
4 8
 
14.
a female that is a whore or has multiple sex partners. Originated in Philly; used in Philly and parts of Delaware.
Jon-ayo she a tweaker. da whole crew hit dat!

or
Jay-yo why did u and yo girl break up? she was fine!
Jon-yeah she was fine but she was a tweaker
Jay-aw man!
by lilmamapullin April 01, 2010
16 20