a tweaker is simply a weirdo, from that weird girl who stalks you, the weird witch lady who lives at number 3 to that crazy old guy with the massive beard who rides his bike around all day muttering. its useful to have in the vocab as it can be shouted with no risk of insult to the tweaker in question. by streachin the sylables it can be made into an almost bird like cry. if u like
tweeeeee-kaaaaaahh
"oh my god, this guy is a fucking stalker, what a tweaker"

"shit dude, did you see that matey wearin girls clothes, what a tweeker"

"whos that tweaker on a microscooter"
by purv of the gore April 26, 2007

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Someone who likes to adjust or fine-tune things; a person who makes small changes to an existing object in order to make it better or to suit one’s preferences
Tessa is known as the Tweaker in her social circle for her knack of turning old fabrics into fashion-forward apparels.
by fln September 23, 2013

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a tweaker is someone who has been doing Crystal Meth for a while and feens for it and is always twitching. Some one who is an addict for Meth.
L. - damn nigga YU're girl is a tweaker aint she?
P. - Ya im going to drop that bitch soon, she fucking up and be doing too much for the dopey
L. - oh, yah how much, give her my number in that case.
by baddxbxtchxdopey August 07, 2010

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Tweaker: Boy/Girl tht go around fuckin everybody . Gettin passed around the whole team or city/place
Boy: there go tht tweaker over there
Girl: How She A Tweak
Boy: The Whole Team Was In Tht Bitch
Girl: Smh Fuckin Whore
by TweeterTweet December 20, 2010

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Someone who Messes around with more than one person.
Christina had sex 5 Guys Last Night. She is Such A Tweaker!
by Mizzjas1802 October 13, 2010

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a whore, a promiscuous female who engages in sexual activity with a lot of people who they have no relationship with.
"man, she'll let anybody hit, she a tweaker."
by k_milly May 10, 2009

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1) A speed, or meth addict who has assumed the role of the drug, in other words, they lost their personality to the drug.
2) An ex- deadhead or hippie who has fried their brain and is now living in the small, paranoid world of warped memories of a mundane adolescence. They communicate by spreading urban legends as "amazing" inspirational stories that align with their perception of reality.
3) A stupid, spastic teen (or adult, but less common) that display ignorance and naivety with every action.
I was walking through the Haight the other day and was surrounded by tweakers.

I went to my high school reunion and the tweakers were still messed up in the head.
by stv October 05, 2004

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being a dumb ass
jim your a fucking tweaker you know that
by tweaker101 July 19, 2010

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