1. To be under the effects of amphetamines, esp. crystal methamphetamine hydrochloride.

2. To be nervous or worried about something, esp. the presence of law-enforcement personnel.
1. Dude I took a fat hit of some dank ice and I'm tweaking balls!

2. Dude I got pulled over with an o in my glove compartment and I was tweaking balls!
by Bri90 January 28, 2010
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Bradley was tweaking after he took crack
by Bradley Fox February 1, 2018
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It's YOUR brand, do what ya' gotta do!
Dude, I helped TWEAK design a shoe!

The TWEAK Rhett & Link Mythical Shoes are the coolest shoes ever check them out!
by TWEAKfootwear April 4, 2011
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To give a girl's clit a real workout, I mean, like when you give it the rub-a-dub taking it between your thumb and index. Not to be confused with mere twiddle.
I was giving her a real tweaking when her mother walked in on us.
by Hugh G Rection October 7, 2003
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