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1.
Anything that goes wrong or ends unexpectedly in any circumstance.
*drops phone*
"PARTY KILL!"

*crashes car"
"PARTY KILL!"

*talks to much*
"PARTY KILL!"

*song skips*
"PARTY KILL!"
by felicha January 10, 2008
 
2.
Derived from partyfoul, a partykill is an action so nonsensical it abruptly ends the party.
After the tacos and margaritas, Reagan thought it would be cool to shit in the middle of the room at the party last night. When it came out diarrhea it was quite the partykill!
by RealNiceG April 21, 2009