When and animal, or human, spends too much time up close to butt holes. This is common in dogs due to their continuous ass sniffing rituals. The inexperienced will inadvertently touch said butt orifice with one or both eyes ... causing a hideous eye infection. Holeyetis
What the fuck dog. Your eye is oozing again with holeyetis. Why do you keep sniffing ass so close!
Metaphorically "killing" one of your friends through betrayal or deception. Basically, turning your back on one of your friends forever. Usually among males, but the term can be used among both sexes.
Damn, you slept with his girlfriend? Man that's homeycide.
I'm sick of him always starting shit at parties. I'm about to commit homeycide on that dude.