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Metaphorically "killing" one of your friends through betrayal or deception. Basically, turning your back on one of your friends forever. Usually among males, but the term can be used among both sexes.
Damn, you slept with his girlfriend? Man that's homeycide.

I'm sick of him always starting shit at parties. I'm about to commit homeycide on that dude.
by ProfessorJT87 March 30, 2010