hightired Share definition Flag A state of exhaustion caused by a lack of sleep and the consumption of marijuana. "Dude, i have only slept for 5 hours in the past two days and I've been smoking all day. I'm hightired." hightired by Steph and Justin January 18, 2009 0 0 Get merch Get the hightired mug. Buy Now — $32.95 See more merch